Intrinsic dynamics study identifies two amino acids of TIMP-1 critical for its LRP-1-mediated endocytosis in neurons
Abstract The tissue inhibitor of metalloproteinases-1 (TIMP-1) exerts inhibitory activity against matrix metalloproteinases and cytokine-like effects.We previously showed that TIMP-1 reduces neurite outgrowth in mouse china glaze beaches and toes cortical neurons and that this cytokine-like effect depends on TIMP-1 endocytosis mediated by the low-d