INTRINSIC DYNAMICS STUDY IDENTIFIES TWO AMINO ACIDS OF TIMP-1 CRITICAL FOR ITS LRP-1-MEDIATED ENDOCYTOSIS IN NEURONS

Intrinsic dynamics study identifies two amino acids of TIMP-1 critical for its LRP-1-mediated endocytosis in neurons

Abstract The tissue inhibitor of metalloproteinases-1 (TIMP-1) exerts inhibitory activity against matrix metalloproteinases and cytokine-like effects.We previously showed that TIMP-1 reduces neurite outgrowth in mouse china glaze beaches and toes cortical neurons and that this cytokine-like effect depends on TIMP-1 endocytosis mediated by the low-d

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Childhood langerhans cell histiocytosis: A bizarre thoracic-spine presentation of a multi-organ disease and a narrative review of the literature

Langerhans cell histiocytosis is a rare disease with diverse clinical presentations.We report a 4-year-old boy with progressive weakness in lower extremities, a large head lump, and inability to walk.On physical 2000 dodge durango catalytic converter examination, bulged scalp, ulcerative skin lesions, engorged veins over the abdomen and chest, and

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A novel two-phase approach for solving the multi-compartment vehicle routing problem with a heterogeneous fleet of vehicles: a case study on fuel delivery

Distribution of goods is one of the main issues that directly affect the performance of the companies since efficient distribution of goods saves energy costs and also leads to reduced environmental impact.The multi-compartment vehicle routing problem (MCVRP) with a heterogeneous fleet of vehicles is encountered when dealing with this situation in

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